Just look at her left eye, it's kind of cloudy, similar to Jolie's eye in one of the photos, where it looks like she has cataracts or something.
In her right eye, you can definitely see a slit. And if you watch the whole video, Madonna seems a little less in control than before, and her eyes seem very reptilian, kind of different than she normally looks. Could it be her reptilian side came out, after she tried to advocate drugs by shouting out at a concert if the kids took ecstasy?
Here's the whole video: http://www.dailymail.co.uk/tvshowbiz/ar ... oking.html
Even the screencapture for the video shows slits in her eyes. Very strange.