George Clooney says he "found the love of my life at 52".

George and Amal Clooney

George and Amal Clooney

The 54-year-old actor - who was previously married to Talia Balsam and enjoyed high-profile relationships with Stacy Keibler and Elisabetta Canalis - tied the knot with 38-year-old lawyer Amal Clooney in 2014 and says he has never been happier than he is now.

George told Esquire: "I've never been happier in a relationship by any stretch of the imagination. At 52 I found the love of my life and I'm really happy."

And George's friends are equally thrilled for him, with the actor revealing his close pal Bill Murray, 65, made a touching speech at their Italian wedding.

He said: "Bill's oddly emotional. He's incredibly warm and emotional. He gave a toast at our wedding that was so elegant and beautiful and warm and he's such a loving individual. And he's adaptable to anyplace he goes. Everybody's life is a puzzle that's missing this one piece, and he fits in each time."

Meanwhile, although he is a hugely successful actor and filmmaker, George revealed his most successful professional venture so far has been his Casamigos tequila brand with his best friend Rande Gerber.

He said: "I have a tequila company, right? It's off-the-charts successful. That's going to end up being the most successful thing I've ever been attached to financially."

And George wants to use his money and success to help less-fortunate people.

He said: "I enjoy the work that I've been lucky enough to do and I wanna keep doing it. I want to remain creative and be able to stay creative as long as they'll let me. So I wanna do that. But as I've gotten older and as I've gotten more secure in my life, there are a lot of other things that I care about more, which is: the people who don't have the luck that I have. There's a lot of people out there who could use some luck. There's a lot of people in this country, but there's an awful lot of people in this world that could use some luck. And sometimes luck is just shedding the spotlight on the fact that their lives are hell."