Seth MacFarlane has broken up with girlfriend Emilia Clarke.

The 'Family Guy' creator has reportedly called time on his romance with the 'Game of Thrones' beauty, and the split is being blamed on the couple's work commitments on different continents putting a strain on their relationship.

A source told E! News: "They are no longer dating. It was really a location challenge. She has been in Europe shooting 'Game of Thrones' and he is based in California, so it was hard to make it work despite the distance. They have remained friends."

The 39-year-old 'Ted' director went public with the actress last September when they appeared together at HBO's Emmy Awards after-party in West Hollywood.

The couple are rumoured to have dated for around six months before splitting.

Emilia, 25, will soon be moving to New York City to appear on Broadway in 'Breakfast at Tiffany's'.

Meanwhile Seth - who had a controversial turn hosting the Oscars last month which was criticised for its risqué nature by some - is currently adapting a new TV show, 'Dads', as well as directing Western comedy 'A Million Ways to Die in the West' and a follow-up to last year's hit teddy bear caper 'Ted'.