Tottenham have had some good news on the injury front as both Eric Dier and Mousa Dembele have been given the all clear.
Dier and Dembele limped off in the second half of the win against Sunderland, as well as Harry Kane, who faces scans on his ankle injury on Monday, but Pochettino said both were suffering from cramp, rather than anything more serious.
Kane, Dier and Dembele all faced Monaco in the Champions League on Wednesday - although Dembele only came on for the second half - and the trio were involved at Euro 2016 with England and Belgium respectively.
"Dier and Dembele only feel cramps in the hamstring, it's not that big an issue," Pochettino said.
"When you're in different competitions, Champions League is a different competition, we spent a lot of energy on Wednesday, it's different to the Europa League. It's new for us so it's important to learn.
"All of them are internationals, they come after a difficult summer, after playing in the Euros. It's difficult with holidays and pre-season and it's difficult to get fit."
Tottenham's victory over the struggling Black Cats means they climb to third in the Premier League table and maintain their unbeaten start to the season.
They managed 31 attempts on goal and had been the dominant force, even before Adnan Januzaj was sent off for a second yellow card late on.
Pochettino had been critical of his side's energy levels in their defeat to Monaco last week but the Argentinian was satisfied, even if it took a hashed clearance from Djilobodji for Kane to break the deadlock.
"It was a good result," Pochettino said. "For the chances we create it's difficult to understand why only 1-0.
"We created many chances but okay, I'm happy with the performance and attitude and the way we played from the first minute. That's the way we need to play every game, not only some games."