Sergio Aguero has declared himself fit after a calf problem but Manchester City will be without Bacary Sagna for up to three weeks.
Striker Aguero was forced off in the 73rd minute of Argentina's 2-2 draw in Peru last week with a calf problem but has insisted he is ready to play on Tuesday night when La Albiceleste host Paraguay.
Meanwhile, City have announced full-back Sagna, who was substituted in the first half of France's 4-1 win over Bulgaria on Friday, has suffered a hamstring pull and is likely to be out until early November.
City manager Pep Guardiola will be watching Argentina's match against Paraguay closely ahead of his side's Premier League home clash with Everton on Saturday and the subsequent Champions League trip to Barcelona.
Aguero, quoted by Argentinian newspaper Ole, said: "You always want to play in the national team and try to do the best, and for now I feel good physically.
"Within five minutes of the second half against Peru I began to feel tiredness in the calf and I was (later) taken off. But I'm quite well now. (Argentina boss Edgardo) Bauza has the decision - I'll be available for Tuesday.
"After the Peru game I had two days to make the recovery and I have played a little bit of football.
"Luckily the pain I had before Peru, which was in the adductor, went away, but certainly to protect the adductor I loaded the calf a little.
"But I'm better. We did tests, they were good and I'm trying to get as fresh as possible for Tuesday."
Aguero admitted his desire to play for his country has created problems for him fitness-wise in the past - such as when he sustained a hamstring injury against Ecuador last season and subsequently missed seven games for his club.
"I wanted to play in Peru, be available and put up with everything I could," the 28-year-old said. "But last season, for wanting to continue, I ended up injured against Ecuador
"Sometimes you think 'why didn't I stop?' Because then I'm out for a month and a half and I miss six or seven games for City.
"But when they call you for the national team, you want to play. That's how it is."