The programme, hosted by comedian Drew Carey, will kick-off its second annual Celebrity Week on 18 February, when stars compete with regular contestants for charity prizes.
And this year Osbourne, Lovato and Lachey have signed up to compete alongside the likes of Glee star NeNe Leakes, retired basketball ace Charles Barkley and Nick's brother and 98 Degrees bandmate Drew Lachey.
Lovato will be hoping to win prizes for youth group Free the Children, while the Lachey brothers will play for Camp Joy, a summer camp for disadvantaged kids.
Osbourne will be competing on behalf of her self-titled colon cancer foundation.
Last year celebrities like Snoop Dogg raised more than $250,000 throughout the week, according to TVGuide.com.