Sarah Silverman has made a decision to prioritise her career over having a family.

The 46-year-old American comedienne has taken to Twitter to honestly admit that she had to make a choice over whether she wanted to have children or be a successful stand-up and actress as the two things are not compatible.

Sarah Silverman
Sarah Silverman

She tweeted: "As a comic always working & on the road I have had to decide between motherhood & living my fullest life & I chose the latter ... So this is just a lil f**k all y'all bc u can't be a woman w/out sacrifice & that's the fact jack. I love my comedian brothers that acknowledge this truth. They're my family & for a lot of us women comic sisters, our only family. (sic)"

Sarah was in an on/off relationship with talk show host Jimmy Kimmel from 2002 to 2009 and is currently dating British actor Michael Sheen.

The 'Frost/Nixon' star has a 17-year-old daughter Lily with his ex-partner Kate Beckinsale and the 'Underworld' star has struck up a friendship with his new beau Sarah and thinks she's a good influence on their child.

Kate said: "I'm completely open to any other strong, cool sensitive independent-thinking women who are going to be an influence in my daughter's life. I am so glad Michael found her."