Holly Willoughby and Christine Bleakley will present 'This Morning' together next month.
The ITV daytime show will break from its tradition of having a unisex presenting duo when regular host Phillip Schofield takes a break to film the new series of 'All Star Mr & Mrs'.
Holly, 32, will team up with the Irish beauty - who often fills in for her when she's absent - on Monday, March 17 and Tuesday, March 18.
'This Morning' editor Adam Vandermark said: "Holly and Christine will make a great new hosting combination - their friendship and love of the show will be reflected I'm sure. 'This Morning' hasn't had an all-female hosting duo for quite a while, so it'll bring a fresh and fun few days for our viewers."
Christine, 35, hosted 'This Morning' with Phillip while Holly was on holiday earlier this year.
Meanwhile, 'The X Factor' host Dermot O'Leary joined Holly on the sofa during Phillip's holiday.
Christine previously presented ITV's 'Daybreak' with Adrian Chiles in 2010 after defecting from BBC, but the pair were unceremoniously axed amid low viewing figures a year later.
The TV star currently hosts 'Dancing on Ice' with Phillip on Sunday evenings.