Wiley has been banned on Facebook and Instagram over his antisemitic tweets.
Following the backlash as Twitter users embarked on a 48-hour walkout over the micro-blogging site's response to the hateful comments, Mark Zuckerberg's firm has completely banned the British rapper from using their apps.
It comes after Twitter imposed a seven-day ban on the 'Wearing My Rolex' star.
An unverified Facebook account under the name Richard Kylea Cowie - Wiley's real name - made nasty remarks about Jewish stars such as Lord Sugar, BBC presenter Emma Barnett and comic David Baddiel.
And Facebook closed down the account on Tuesday (28.07.2), along with his official accounts.
A rep for Britain's Prime Minister Boris Johnson had criticised the response from social media outlets.
The spokesperson stated: "Social media companies need to go much further and faster in removing hateful content such as this."
The UK's Secretary of State for the Home Department, Priti Patel, had earlier blasted Twitter and Instagram for not removing the rapper's antisemitic comments soon enough, and joined a number of celebrities and politicians in boycotting the app in response to the hateful tweets, which are being investigated by police, being left online too long.
The likes of 'Harry Potter' actor Jason Isaacs and singers Sophie Ellis-Bextor and Jessie Ware have been avoiding using the app since 9am Monday (27.07.20) in protest.
In a statement posted on Twitter, Patel fumed: "The antisemitic posts from Wiley are abhorrent.
They should not have been able to remain on Twitter and Instagram for so long and I have asked them for a full explanation.
Social media companies must act much faster to remove such appalling hatred from their platforms."
The new campaign in response to Wiley's tweets is called #NoSafeSpaceForJewHate.
John Woolf - who had been the 41-year-old rapper's manager for a number of years - said A-List Management had "cut all ties" with Wiley after he compared Jewish people to the Ku Klux Klan in a Twitter tirade on Friday (24.07.20).
Woolf, who is Jewish, tweeted: "Following Wileys anti semitic tweets today we at @A_ListMGMT have cut all ties with him. There is no place in society for antisemitism."
The Grime star - whose real name is Richard Cowie - had tweeted: "Listen to me Jewish community Israel is not your country I'm sorry ... The Star of David that's our ting ... Some people have gotten too comfortable on lands that don't belong to them.
"There are 2 sets of people who nobody has really wanted to challenge #Jewish & #KKK but being in business for 20 years you start to undestand [sic] why ... Red Necks Are the KKK and Jewish people are the Law...Work that out. If you work for a company owned by 2 Jewish men and you challenge the Jewish community in anyway of course you will get fired.
"Forget anti Semitic racism is racism and ya can't hide the fact that systemic racism exists and it wasn't set up by us (sic)."
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