The couple married on 12th June 1999 after they met on the set of Scream and Friends. They both gave up smoking just before their wedding day. Cow's wedding ring was allegedly engraved with the words 'a deal is a deal'.
Cox was once asked about the moment just before they started living together; 'Before he moved in, David would say 'How are we ever going to meld together, because our tastes are so different? Maybe it's because we're truly in love that we can.' (IMDB)
Their daughter Coco Riley Arquette was born on 13th June 2004.
On October 11th 2012, the pair announced their split, however still maintain a close business relationship (for their production company Coquette) and friendship.
In June 2012, Arquette filed for divorce, two years after he separated from Cox and it was all finalised by May 2013.
Source: Wikipedia and IMDB.